Physical properties of aspirin. Armed with an understanding of how these drugs act, and their potentially harmful aspects, the athletic trainer can assist the team physician in designing an aspirin- or NSAID-therapy regimen. Mass of Aspirin = 5. In nature, it is weakly acidic. Melting Point: Aspirin has a melting point of around 135-140°C. This includes physicochemical properties of the compounds as well as methods for determination of aspirin and its metabolites. Acetylsalicylic Acid other Aspirin Jul 14, 2020 · Background The cocrystallization process in pharmaceuticals has gained widespread attention as a recent method of modifying physicochemical properties without altering the pharmacological characteristics of drugs. A fourth bond links the carbon atom to a hydrogen (H) atom or to some other univalent combining group. 07) Parent Compound. Chemical property Physical property Answer Bank Aspirin reacts with sodium Hydroxide to form two new compounds Aspirin is a solid at room temperature and melty at 136 "C. Background: Aspirin is recommended as a first-line antiplatelet drug for all types of acute diseases that cause thrombosis in the blood vessel, especially in cardiovascular disease Step 1. It is also used to prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. The only time the aspirin has an odor is in moist air. 0 mg/mL TPP (Figure 2(d)) showed a clear melting peak at 139°C which is almost the same with Figure 2(b) and the little peaks during 150–160°C disappeared, indicating the physical connection between aspirin and CS-NPs. Molecular weight of acetylsalicylic acid – 180. Acetylsalicylic acid (aspirin) is an acetic acid ester derivative of salicylic acid, with a chemical formula C9H8O4. While daily aspirin can help prevent a clot-related stroke, it may increase the risk of a bleeding stroke. Jan 24, 2021 · COSURFACTANT ON THE PHYSICAL PROPERTIES OF ASPIRIN MICROEMULSION. Chemical Formula: Aspirin, also known as acetylsalicylic acid, has a chemical formula of C9H8O4. [52] It plays a role in the resistance to pathogens (i. Aspirin is broken back down in the intestines to reform salicylic acid, which is in Plant hormone. Nov 2, 2015 · 8. brynnm26. Oct 30, 2017 · The physical appearance, rheological properties, and concentration of Celecoxib in the selected emulsion remained unchanged after storage for 3 months. Before repackaging the amount of aspirin was found to be 69. 1 liter of water can dissolve 3 grams of Aspirin. Study with Quizlet and memorize flashcards containing terms like properties describe matter, properties of a substance can be observed, one can use their five senses to determine the properties of a substance and more. The drug has anti-inflammatory properties. [51] Salicylic acid is involved in endogenous signaling, mediating plant defense against pathogens. Figure 1. Aspirin has been a common household product for decades. Mixed quality of trials as 5/9 were double-blind, 6/9 used ITT and most had <6% loss to follow up. It is probably the most commonly used over-the-counter medication. It consists of nine carbon (C) atoms, eight hydrogen (H) atoms, and four oxygen (O) atoms. It is odorless, small white needle-like crystals or light crystalline powder. INTRODUCTION Aspirin, the ubiquitous pain reliever, goes by the chemical . 40 g mL-1. , 2015, Wang et Aug 2, 2022 · A physical property is a characteristic of a substance that can be observed or measured without changing the identity of the substance. Aspirin is a white, crystalline powder. The primary distinction between the changes due to a process are whether or not the chemical identity of the substance changes with the process. Oct 4, 2023 · Physical Properties of Aspirin. The taste of Aspirin is bitter. Likewise, the extended formula for the same is CH3COOC6H4COOH. The method of purification is based on the principle that the solubility of most solids increases with increased temperature. Therefore, aspirin can be used in an exercise-induced inflammatory response, chronic pain, or inflammation-induced cancers. Worsen asthma. Step 3. It also has a molecular mass of around 180. Taste: There is no taste. Molecular Weight. 15 3. A bleeding stroke also is called a hemorrhagic stroke. In this reaction, salicylic acid May 7, 2021 · Molecular Formula. Acetylsalicylic acid, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C , and a boiling point of 140 °C . 1 Origin of the substance Usually prepared by acetylation of salicylic acid with acetic anhydride, using a small amount of sulphuric acid as catalyst. Aspirin may look different in each tablet you take, but the inner part of the tablets all look the same. Its boiling point is 140 ℃. Avbunudiogba and Omonyemen Edoise Cash-Torunarigha and Dec 15, 2020 · Physical Properties; Physical description Odorless, colorless to white, crystal-line powder. To calculate the atomic charge of aspirin, the Mulliken atomic charge was observed. Aspirin Uses. The physical properties of Aspirin are: Odorless, Colorless, and it can be a crystalline powder. 9790/3008-0752025 Corpus ID: 1595908; Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods @article{Avbunudiogba2013EffectOH, title={Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods}, author={John A. 22mg. 159 g mol-1. 180. If the identity does not change, the process induces only a physical change. The chemical properties of calcium are The story of Aspirin – a versatile medicine with a long history. (BEIs) - Acetylsalicylic acid (Aspirin). It is odorless but might have a faint odor of acetic acid. 3. 1 Toxicity Summary. YATI, KORI. Background: Aspirin is recommended as a first-line antiplatelet drug for all types of acute diseases that cause thrombosis in the blood vessel, especially in cardiovascular disease Aspirin has been a common household product for decades. Oct 7, 2011 · The results reveal that electron delocalization via the n → π* interaction has significant and heretofore unappreciated effects on the physical and chemical properties of aspirin. Physical Properties. Aspirin has 9 Carbon atoms, 8 Hydrogen atoms, and 4 Oxygen atoms ("Aspirin: MedlinePlus Drug Information", 2015. 3g of Aspirin can dissolve in 1 liter of water. Chemical properties. 3 g/mol. It is used in manufacturing many sodium salts, as a source of carbon dioxide, ingredient of baking powder, and effervescent salts and beverages, in fire extinguishers, cleaning compounds. Although not a NSAID, acetaminophen has many important clinical uses. It's soluble in water. In general, the process of water transport is a function of the physical state of the lipid bilayer and its structure, 37 and water permeability itself properties of the crude product with the properties of aspirin which is recrystallized in a variety of solvent systems 9,10 . In both batches the aspirin content failed to meet BP requirements as they weren’t within 95% Jan 1, 2022 · Moreover, aspirin was found to be more effective in reverting ethanol-promoted changes in blood constituents. To investigate the properties of purified acetyl-salicylic acid for Dec 2, 2023 · The different physical properties of the polymorphs make Form II considerably softer than Form I. To investigate the properties of purified acetyl-salicylic acid for Oct 30, 2017 · A form of microemulsion was used to prevent hydrolysis of aspirin because it contains a high concentration of the surfactant and cosurfactant and the results showed that the formula F3 was the most stable formula. 3 Physical properties 3. Background: Aspirin is recommended as a first-line antiplatelet drug for all types of acute diseases that cause thrombosis in the blood vessel, especially in cardiovascular disease. Some of the adverse effects of Aspirin are: Stomach ulcer and stomach bleeding. Dec 1, 2016 · properties of t he crude product with the pr operties of aspirin which is recrystallized in a variety of solvent systems 9,10 . This means that as temperature increases, the amount of solute that can be dissolved in a solvent Apr 5, 2018 · Aspirin samples treated with γ-ray, UV-lamp, sunlight and 40 °C temperature were prepared. The carboxyl (COOH) group is so-named because of the carb onyl Concludes that aspirin does not exist in polymorphic forms; TRC: 412. Made How Volume 1 (2015). 05. The aim of this study was to investigate the effect of Tween 80 and propylene glycol as Organoleptic a surfactant and cosurfactant on the physical properties of aspirin Organoleptic includes observation of the shape, clarity, and smell. Physical Properties of Aspirin – It Shows Following Physical Properties . properties of the crude product with the properties of aspirin which is recrystallized in a variety of solvent systems 9,10 . Sign In. 1800-120-456-456. williamsphi23. Physical Properties of Salicylic Acid. These beneficial influences of ethanol on aspirin bioavailability encouraged us to study the molecular interactions between aspirin and hydro-ethanolic dissolution media by studying and analyzing their physico-chemical properties. In this letter, Gordon explains that aspirin sales are generally steady all year, despite some spikes. May 14, 2010 · 1,317 women. Computer-aided drug designing methods are popularly used in structure-based drug design (Åqvist et al. Feb 23, 2024 · carboxylic acid, any of a class of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom by a double bond and to a hydroxyl group (―OH) by a single bond. Its' chemical formula is C9H8O4. It is made up of white crystalline powder. Early evidence suggests there are beneficial effects of aspirin in preclinical and clinical studies in mood disorders and schizophrenia, and epidemiological data suggests that high-dose aspirin is associated with a reduced risk of AD. Oct 20, 2023 · Uses Of Acetylsalicylic Acid. aspirin acetylsalicylic acid. Jan 3, 2020 · A combined experimental and computational approach was used to distinguish between different polymorphs of the pharmaceutical drug aspirin. The melting point is 136 degrees Celsius (277 degrees Fahrenheit). The salicylic acid molecule has two hydrogen bond donors and three hydrogen bond acceptors. Pharmaceutical cocrystallization of active pharmaceutical ingredients (APIs) with other pharmaceutically accepted coformers is an effective way to modulate API pharmaceutical properties, such as solubility, dissolution rates, stability and tabletability, without altering their pharmacological activities (Cheney et al. Aspirin may cause fever also. Chemical properties Dec 13, 2022 · Addeddate 2022-12-13 15:02:15 Identifier physical-and-chemical-properties-of-aspirin Identifier-ark ark:/13960/s2n9mx03dgg Ocr Aspirin is a carboxylic acid ester derived from salicylic acid, which itself is synthesized from the phenolic compound salicin. At 25 °C (77 °F), its acid dissociation constant is 3. Computed by PubChem 2. Crystalline solid is the natural state. Sign By. 5 at 25 °C. ). Physical Characteristics of Acetyl Salicylic Acid. Molecular Weight: 180. 1994 ). Unlock. Aspirin is one of the most widely used, commercially available pharmaceutical drugs in the world. Its acid dissociation constant is 3. When taken in regular doses, Aspirin leads to an upset stomach, heartburn, drowsiness or even mild headache. A chemical titration was used determine the content of aspirin. Physical properties include color, density, hardness, and melting and boiling points. Headache: Aspirin, either by itself or in a combined formulation, effectively treats some types of headache, Fever: Like its ability to control pain, aspirin's ability to control fever is due to its action on the prostaglandin system . The molecular structure of acetylsalicylic aci d (Aspirin). Physical Change: Physical changes are changes in the form or structure of a given substance as a result of a given process. Gastrointestinal bleeding. It is a Jan 1, 2013 · PDF | On Jan 1, 2013, John A. The elusive form II of aspirin has been obtained during co-crystallization experiments with levetiracetam or acetamide, and it has been characterized by IR, DSC, HPLC, and single-crystal X-ray diffraction. Given: mass of Salicylic acid = 2. Aspirin is a white, crystalline, mildly acidic chemical with a melting point of 136 °C (277 °F) and a boiling temperature of 140 °C (284 °F). Irritation in genital part, palms, and toes. Jul 24, 2023 · molecular structure of aspirin is displayed in Figure 1, and its various properties are presented in Table 1. Aspirin is a more potent inhibitor of prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives. Aspirin has a melting point of 136 degrees and a boiling point of 140 degrees. Introduction. The chapter discusses the chemical structures and physicochemical properties of aspirin and other salicylates, and Mar 18, 2013 · Aspirin can reduce oxidative stress and protect against oxidative damage. Blood comes out while coughing. Ancient history has many examples of humans using salicylic acid for medicinal purposes; there are clay Jan 21, 2014 · • • • • • introduction physical properties preparation reaction mechanism uses and mechanism of action on body • side effects 3. Water dissolves it. 136°C is its melting point. This is not the case with aspirin. , 2011, Perumalla and Sun, 2013, Surov et al. Swelling of skin tissues. 5. Salicylic acid is a colourless, odourless and needle-shaped crystals at room temperature. It has got no odor. While the prophylactic use of regular, low dosage, acetylsalicylic acid (aspirin) has been employed due to the inhibitory effect on platelet aggregation, few if any rheological studies validate the change in the physical and mechanical properties of human blood post-aspirin administration. Mar 25, 2022 · 1. 2 Chemical structure COOH O-CO-CH 3 2-acetoxy-benzoic acid C 9 H 8 O 4 Molecular weight 180. 1 Properties of the substance Colourless Oct 1, 2020 · Properties of Aspirin and its Effect on the Body, November 2019. 16 g/mol and a density 1. It has got atomic mass of 180. Aug 29, 2022 · What is a physical property of aspirin? August 29, 2022 by Alexander Johnson. The molecule is formed by an aromatic ring with two functional groups in position -orto: carboxylic acid as the first substituent Physical properties. The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources. Question: Aspirin is a substance that is commonly used as a pain reliever. Cocrystallization provides a couple of benefits like it can be employed for a large number of APIs (acidic, basic, ionizable, or non-ionizable), and secondly, the availability of a Dec 18, 2018 · It is the responsible pharmacists” duty to guarantee the safe supply of medicines. The boiling point and melting point of salicylic acid are 211oC and 315oC respectively. 5°, and pyramidalization parameters Δ = 0. Acetylsalicylic Acid has the chemical formula C9H8O4. 6 days ago · Chemical Properties of Salicylic Acid (Reactions of Salicylic Acid) Formation of Aspirin: In the pharmaceutical industry, the most important reaction associated with the use of salicylic acid is the production of aspirin (acetylsalicylic acid), one of the most commonly used analgesics and blood-thinning agents. It is the preferred alternative analgesic-antipyretic to aspirin (acetylsalicylic acid), particularly in patients with coagulation disorders, individuals with a history of peptic ulcer or who cannot tolerate aspirin, as well as in children (American Medical Association, 1986 ISSN - 0975-7058 Special Issue (October) EFFECT OF OPTIMIZATION OF TWEEN 80 AND PROPYLENE GLYCOL AS A SURFACTANT AND COSURFACTANT ON THE PHYSICAL PROPERTIES OF ASPIRIN MICROEMULSION. Its molar mass is 180. This research was a valuable contribution to our understanding of this common drug. 011 properties of the crude product with the properties of aspirin which is recrystallized in a variety of solvent systems 9,10 . e Let us note the physical and chemical properties of Aspirin. Cole 2009 [ 60] 4 trials. The interaction parameters of the GN (Equation 11) and JA (Equation 12) models fitted to the experimental data of the physical properties of the two ternary systems studied at temperatures of 25, 40 and 55 °C are shown in Tables S6 and S7 of the Supplementary Material. Speaks in our experts. In moist air, the aspirin smells like acetic acid. 3. 0 g. Aspirin or acetylsalicylic acid is a commonly used pharmaceutical used for pain relief, reducing fevers, and inflammation. 2004 ). Risk of pre-eclampsia and pregnancy outcomes. May 19, 2021 · The content of pendant aspirin was readily modulated by monomer feeds during ring-opening polymerization, and the copolymers with ∼10% or less aspirin pendants exhibited gigapascal-tensile moduli at body temperature and significantly improved fracture toughness and energy dissipation that positively correlated with the aspirin pendant content. It appears as colorless to white crystals or crystalline powder. Aspirin therapy before <16 weeks was associated with reduced pre-eclampsia, severe preeclampsia and gestational hypertension. 360. Often, public health officials use sales rates of over-the-counter medication to predict disease outbreaks in a community. See annual publication for 4 days ago · aspirin, derivative of salicylic acid that is a mild nonnarcotic analgesic ( pain reliever) useful in the relief of headache and muscle and joint aches. Finally, the UV-Vis, FTIR, and Raman spectra of the title molecule are analyzed and compared with the experimental data. 140°C is its boiling point. It has a smell similar to that of vinegar. Oct 25, 2023 · Few adverse effects are reported with intake of Aspirin. Aspirin is white is color. It is an acetyl derivative of salicylic acid. A chemical property describes the ability of a substance to undergo a specific chemical change. This smell is because of the hydrolysis yielding salicylic and acetic acid of Acetylsalicylic Acid. 1 (PubChem release 2021. Salicylic acid is a phenolic phytohormone, and is found in plants with roles in plant growth and development, photosynthesis, transpiration, and ion uptake and transport. Preview. 16 g/mol is its molar mass. Considered to represent a broad spectrum of physical characteristics of powders used in pharmaceutical processing, they include actives, aspirin and paracetamol, and bulk excipients (additives used to improve the binding properties of the bulk drug during tabletting or as a carrier to aid absorption into the body). Talk up our authorities. DOI: 10. Barranquilla and Cartagena, were evaluated in terms of their physical, chemical and Jan 1, 2022 · Moreover, aspirin was found to be more effective in reverting ethanol-promoted changes in blood constituents. Jun 1, 2014 · A thermogram of aspirin loaded CS-NPs with 4. It is weakly acidic in nature. View Show abstract Chemical and Physical Properties of Aspirin. Acetylsalicylic Acid or Ace Feb 8, 2021 · Request PDF | On Feb 8, 2021, ammar Aziz and others published Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese IUPAC Standard InChIKey: BSYNRYMUTXBXSQ-UHFFFAOYSA-N Copy CAS Registry Number: 50-78-2 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file Feb 15, 2024 · Mathematical description of the physical properties of the ternary systems. Though it is a pain reliever, it may cause swelling or pain lasting longer than ten days in some patients. Acetylsalicylic acid also known as ASPIRIN is a salicylate drug, often used as an analgesic, antipyretic and anti-inflammatory medication. Surprisingly, recent studies suggest that some NSAIDs may hinder the healing process. To investigate the properties of purified acetyl-salicylic acid for Sep 6, 2023 · Pulverizing an aspirin tablet is a physical change (it is not a property at all). Physical properties. physical and chemical properties of Aspirin, giving insight into its potential applications. 93 g. 1. Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C (277 °F), and a boiling point of 140 °C (284 °F). Aspirin (Asp) or acetylsalicylic acid is a member of nonsteroidal anti-inflammation drug (NSAID) and commonly used as analgesic Speaking at our specialized. SCHEMBL7580. IDENTIFICATION AND USE: Sodium bicarbonate is a white crystalline powder or granules. 14. 48mg which then decreased to 69. Feb 13, 2024 · Molecular Electrostatic Potential (MEP) was employed to understand the physiochemical properties of aspirin. Synthesis The synthesis of aspirin is classified as an esterification reaction. It is a relatively simple molecule that was discovered and developed in the 1950s and 1960s at Boots Pure Drug in Nottingham, UK (now Boots UK in Beeston). Physical and Chemical Properties of Acetylsalicylic Acid. Preparation: The preparation of Aspirin is an example of an organic synthesis called esterification. Aspirin, one of the oldest agents in Jan 30, 2023 · Recrystallization, also known as fractional crystallization, is a procedure for purifying an impure compound in a solvent. • Two thermal degradation steps occurred for the Aspirin samples. 4 g/cm3 at 20°C. Generally, Acetylsalicylic Acid is colourless to white crystalline solid. Acetylsalicylic Acid is given shortly after a heart attack because it decreases the risk of death. Crystal structure of acetylsalicylic acid 9m and its Bürgi– Dunitz parameters d = 2. Jun 10, 2016 · Aspirin and salicylic acid are stable compounds and are poorly water soluble at acidic and neutral pH. Avbunudiogba published Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods | Find, read and cite all PHYSICO-CHEMICAL PROPERTIES 3. Aspirin is effective in reducing fever, inflammation, and swelling and thus has been used for treatment of rheumatoid arthritis, rheumatic fever, and mild infection. much more physical and chemical property data is available from the following TRC products: The scientific name for Aspirin is Acetylsalicylic Acid. It is a white crystalline solid at room temperature. The effect of aspirin begins within 30 minutes for pain or fever. Its IUPAC name is 2- (acetyloxy)benzoic acid. Although aspirin's use as an antipyretic in adults is well-established, many medical societies and regulatory agencies strongly advise against using aspirin Jan 24, 2023 · Severe nausea, vomiting, or stomach ache. ch 3 - physical or chemical changes. At room temperature, it is a white crystalline solid. Aspirin, or acetylsalicylic acid (ASA), is a derivative of salicylic acid (SA) that is used as an analgesic (reduces and prevents pain) and antipyretic (reduces or prevents fever) medication. Spread the love. • Some treated Aspirin samples showed lower E a and thermal stability than the untreated one. The chemical nature of the aspirin does not change when it is pulverized. • Significant physical changes were observed in the XRD and SEM results of some treated Nov 11, 2023 · To assess changes in the bilayer physical properties, the parameter of passive water permeability was used as a metric to gauge perturbations in membrane organization owing to ASA interactions. Abstract. Redness of eyes, toes, feet. KORI YATI Aug 5, 2003 · The materials used in this work are listed in Table 1. Table of Contents show. May 18, 1999 · Aspirin ethylcellulose microcapsules were tableted by compression with or without excipients (lactose or polyvinylpyrrolidone [PVP]). Its properties make it a powerful analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory (reduces swelling) drug. 6 days ago · Properties of Aspirin . Write a balanced reaction for the formation of asparin View the full answer Step 2. Calculate the percent yield of your synthesis. 45 terms. Test the purity your aspirin sample by melting point and by reaction with FeCl. Acetylsalicylic Acid otherwise Aspirin May 14, 2018 · Ibuprofen is a frequently used over-the-counter drug for treating pain, inflammation, and fever. Question: The Synthesis and Analysis of Aspirin OBJECTIVES In this experiment, you will Synthesize a sample of acetylsalicylic acid (aspirin). The effects of the amount of the excipients and microcapsule size on the crushing strength and release rate of aspirin from tableted microcapsules were investigated. Essentially, all methods of synthesis are Physical Properties. Aspirin is acetylsalicylic acid, or salicylic acid acetate and 2- (acetyloxy)-benzoic acid. Mar 4, 2020 · Structural modification is one of the important way to design a new potential drug (Li et al. 16 g/mol. This method involves the use of ab initio random structure searching (AIRSS), a density functional theory (DFT)-based crystal structure prediction method for the high-accuracy prediction of polymorphic structures, with DFT calculations of nuclear magnetic Nov 12, 2023 · Aspirin is used as an antiplatelet drug at lower doses (75 to 325 mg) to reduce cardiovascular events in high-risk patients. [3]. Usually, Aspirin is prescribed by a physician or pharmacist. The differences in activity are thought to be due to the acetyl group on aspirin, which is responsible for the irreversible inactivation of cyclooxygenase. Another common name for Aspirin is ASA. Observations were carried out for 6 weeks, on weeks 0, 3, and 6. Synonyms. 16 g mol − 1 ^{-1} − 1. The crystalline powder is usually odorless. Mar 29, 2024 · Physical properties. Acryl salicylic acid, also known as aspirin, is a chemical compound with the physical properties listed below. White odour: the absence of odour. Aspirin Physical Properties. Topic 14: Redox II. Herbal medicine has used salicylic acid, the natural substance related to synthetic aspirin, from myrtle, willow and meadow sweet, since ancient times (at least 2500 BCE). microemulsions. 90 Å and θ = 99. The taste of salicylic acid is acrid. Its melting point is 136 ℃. The initial British patent on ibuprofen and a long list of similar compounds was awarded to Apr 20, 2023 · Side effects and complications of taking daily aspirin include: Stroke caused by a burst blood vessel. C18H16O8. 17 terms. Paracetamol is used as an analgesic and antipyretic drug. The compound’s molecular formula is C 9 H 8 O 4, and it is characterized by the presence of a benzene ring (aromatic ring) with a carboxylic acid and an ester group attached. Classify each of the following properties of aspirin as chemical or physical. Jan 1, 1979 · This chapter presents the nomenclature, physical properties, synthesis, and methods of analysis of aspirin. Similarly, the density of it is 1. Answer.
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